An ingredient that enhances a powder’s flowability is known as a glidant. Concentrations of a glidant must fall within a certain range to be effective. The glidant really inhibits flowability when concentrations are raised over a threshold. Glidants are often introduced right before compression in the tablet manufacturing process. Talc, starch, colloidal silica, and silicates are all popular glidants in the pharmaceutical sector. Among them is talc, which has long been used as a glidant.
The granules of a formulation will flow up to a particular optimal concentration if certain substances are used. The flow rate may be reduced if the glidant concentration exceeds this optimal concentration.
An example of a glidant is ascorbyl palmitate; calcium palmitate; magnesium stearate; fumed silica (colloidal silicon dioxide); starch and talc are more examples.
To counteract variables that lead to poor powder flowability, glidants are used. Correcting surface irregularity, minimising inter-particular friction, and lowering surface charge are a few examples of these techniques in action. The angle of repose decreases as a consequence, which indicates an improved flowability of the powder.
