To prevent the tablet from sticking to the skin, anti-adherents are included in the tablet’s chemical composition. As a result, the term “non-sticking agents” is appropriate. These chemicals may prevent the tablet surface from adhering to the wall of the cavity in which the tablet is made. We may employ water-insoluble lubricants like magnesium stearate, talc, and starch as anti-adherents since they are water-soluble.
Antiadherents with the highest performance are silicas, such as silicon dioxide and calcium silicate. In addition to talc and leucine, lubricants like these include anti-adhesive qualities like stearic acid or sodium stearyl fumarate. Because of their absorbent qualities, MCC and Starch might be considered antiadherent. Gliding qualities of several antiadhesives aid in powder flow.
Lubricant Glidant vs. Anti Adherent: What’s the Difference?
Tablet and capsule formulations benefit greatly from the use of lubricants, which act to minimise friction. More crucially, the friction between the particles used to compress the pill is reduced by these compounds. Powders may be made to flow more easily with the use of glidants. The powder we utilise to make tablets also has a higher flow rate as a result of this process. To prevent the tablet from sticking to the skin, anti-adherents are included in the tablet’s chemical composition. Because these compounds prevent the tablet surface from adhering to the wall of our tablet manufacturing cavity, they are critical. A tabular comparison of lubricant glidant and anti adherent is shown in the following infographic.
